FAS Research Core Facilities

The Faculty of Arts and Science’s core scientific facilities provide faculty, researchers, and students with an array of specialized equipment, technologies, and services to support innovative research. These cores offer a wide variety of services and instruments. Fees, access, and required training vary by core. A comprehensive list of research cores at Harvard University and affliiate institutions is available through Harvard Catalyst

 

Bauer Flow Cytometry Core

The FAS Division of Science's Bauer Flow Cytometry Core provides cell sorters, analyzers and particle counters on which are offered a combination of training and service.
 

 

Bauer Sequencing Core

The FAS Division of Science's Bauer Sequencing Core supports massively parallel high throughput sequencing using our Illumina NovaSeq, HiSeq, and NextSeq instruments. These sequencers can generate billions of bases of data per run and enable a wide variety of applications. Researchers can choose either single or paired-end reads. Multiple samples can be indexed (barcoded) and be combined in order to make the most of the system's output. The core offers training, support, and fee-for-service work and provides access to ancillary equipment for sample preparation. 
 
 

CCB Center for Crystallographic Studies (X-Ray Core)

The CCB X-Ray Core provides researchers with single crystal X-ray data collection, structure solution, and refinement of small molecule structures.
 

 

CCB Nuclear Magnetic Resonance (NMR) Core Facility

The CCB NMR Facility offers access to 11 spectrometers, including 7 NMR, 1 EPR, 1 MS, 1 IR, and 1 MPMS
 

 

Center for Brain Science Neuroimaging Core

Offers access to a 3-Tesla magnetic resonance imaging scanner for non-invasive human brain imaging as well as an MR simulator,  a transcranial magnetic ttimulation laboratory, a near infrared spectroscopy (NIRS) laboratory, and other supplementary equipment. The core is part of the Center for Brain Science, which also operates the following additional cores: Neuroengineering, Light Microscopy,  and Electron Microscopy.
 

 

Center for Nanoscale Systems

The Center for Nanoscale Systems (CNS) is a shared-use core facility. Our scientific focus is the study, design and fabrication of nanoscale structures and their integration into large and complex interacting systems.The CNS is a “build and test” laboratory facility supporting: cleanroom fabrication and characterization of nanoscale devices and structures; electron-beam imaging and analysis tools; materials characterization including XPS, microCT, PL, FTIR, AFM, microfluidic processing and a cell culture and microscopy facility. CNS is a member of the National Science Foundation’s National Nanotechnology Infrastructure Network (NNIN) initiative to create a national network of world-class facilities available to all researchers.
 

 

FAS Research Computing

FAS Research Computing facilitating the advancement of complex research by providing leading-edge computing services. Research Computing staff maintain expertise in constantly changing computing technologies, while “speaking the language” of FAS researchers, to help them use computing more effectively.  Computational resources are available for high performance and scientific computing, visualization, and data storage. Research Computing continually expands its services and technologies, ensuring researchers have access to a world-class computational environment.

 

Genome Modification Facility

MCB's Genome Modification Facility (GMF) provides transgenic, gene targeting, and other services. The GMF performs microinjections of DNA into fertilized embryos to generate transgenic mice, DNA transfection into ES cells for the creation of recombinant ES cell clones, injection of gene-targeted ES cells into host blastocysts to generate gene knock-out or knock-in mice, teratoma formation studies, and other related ES cell-based services. The GMF also generates preps for gRNA validations, and performs microinjections of TALENs or CRISPR/Cas9 and sgRNA as well as DNA donors into mouse zygotes for gene editing projects. Other services include cryopreservation of mouse sperm and embryos, in vitro fertilization, recovery of cryopreserved mouse sperm and embryos, rederivation of pathogen free mouse lines, and establish new ES cell lines from wild type and mutant mice with a variety of genetic backgrounds.
 

 

Harvard Center for Biological Imaging (HCBI)

The FAS Division of Science's Harvard Center for Biological Imaging (HCBI) is one of the most innovative biological imaging centers in the world. Imaging systems at the HCBI are leased rather than purchased and replaced every 2-3 years. This ensures that the facility remains relevant and is never in possession of outdated equipment. Currently, the HCBI contains 18 microscopes and high-end processing stations including confocal, super-resolution, multi-photon, lightsheet, live cell imaging, high-content screening, slide scanning, laser dissection and macroscopy. The facility also features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for a wide range of species.
 
 

HSCI iPS Cell Core Facility

The Harvard Stem Cell Institute's iPS Cell Core Facility provides investigators with customized iPS derivation and genome editing based on the latest cutting-edge stem cell technologies.  The core offers three non-integrating technologies (Sendai virus, miRNA and modified mRNA, and episomal vector) for reprogramming of a variety of somatic cell types. They also offer the generation of genome engineered hESC or hiPS lines. We currently offer TALEN or CRISPR genome editing technologies to generate knock-out or knock-in lines for repair or introduction of mutations. The iPS Core also serves as a repository for Harvard hESC lines and both control and disease-specific hiPS cell lines.
 

 

Informatics & Scientific Applications Core

The FAS Division of Science's Informatics group provides bioinformatics analysis support for all users of the core sequencing facility and to FAS faculty groups regardless of the origin of their data.    In addition we have the responsibility for sample submission, tracking, scheduling and billing services for many of the core instrument facilities across FAS.

 

Mass Spectrometry and Proteomics Core

The FAS Division of Science's Mass Spectrometry and Proteomics Resource Laboratory provides mass spectrometry and strategic consulting in proteomics by bringing together the state-of-the-art expertise and instrumentation.  The core offers access to instrumentation used for protein characterization and quantitation and  offers numerous services, from protein identification to C-terminal sequence analysis to intact protein molecular weight determination by ESI.
 

 

Office of Animal Resources (OAR)

The Office of Animal Resources (OAR) is the central animal care department for Harvard's FAS campus. Services provided by OAR include: research animal procurement from commercial vendors, import of animals from and export of animals to academic institutions; daily animal care and health assessment; veterinary care; infectious disease monitoring; animal quarantine; and research model/protocol consultation.

 

Physics/SEAS Electronic Instrument Design Lab

The Lab provides work space, tools, parts, and technical assistance for Physics/SEAS students and faculty who need to design and build custom electronic instruments. The Lab staff can assist with schematic and circuit board design, help order parts, provide soldering/assembly instruction, and help debug circuits. Alternatively, we can start from your specifications and develop fully custom instrumentation to meet your needs.

Manager: James MacArthur

 

Physics/SEAS Instructional Machine Shop

The Instructional Physics/SEAS Machine Shop, located in the basement of Lyman Lab, is set up to be primarily a teaching shop for the Physics Department and the School of Engineering and Applied Sciences. We have a state-of-the-art facility, complete with computerized machine tools and full arc welding capabilities.

 

SCRB Flow Cytometry Core

The SCRB Flow Cytometry Core is dedicated to mammalian cell sorting and analysis.  The core offers access to a variety of cell sorters and analyzers.
 

 

SCRB Histology Core

The SCRB Histology Core offers an array of full service professional and techical histological and immunohistochemical services. The Core Histologists can advise and assist with experimental design and development and will assist you with interpretation of tests and their results. Technician are also available do your specialized histology and immunohistochemistry on a fee-for-service basis.
 

 

Small Molecule Mass Spectrometry Core

The FAS Division of Science's SMMS Core offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. The core provide services for molecular formula confirmation, structural elucidation (MS/MS) and quantitation of small molecules.  In addition, the core can assist you in the mass analysis of a wide variety of  samples including metabolites, medium-sized proteins, and oligonucleotides.