Core Facilities

Harvard University’s core scientific facilities provide faculty, researchers, and students with an array of specialized equipment, technologies, and services to support innovative research. Twenty different cores operate under the Division of Science. These cores offer a wide variety of services and instruments. Fees, access, and required training vary by core.

Harvard Center for Biological Imaging (HCBI)

Offers access to 20 different high-powered imaging microscopes. Registration and laser safety training is required for all users.
Faculty Director: Jeff Lichtman

Sequencing Core

Offers access to high throughput “next generation” sequencing using Illumina technology and capillary-style Sanger sequencing. The core offers training, support, and fee-for-service work and provides access to ancillary equipment for sample preparation. 
Faculty Director: Gonzalo Giribet

Flow Cytometry Core

Offers access to several cytometers for experiments, training and other services.
Faculty Director: Andrew Murray

Microarray Core

Offers access to instruments for analyzing, creating, and processing microarrays.

Mass Spectrometry and Proteomics Core

Offers access to instrumentation used for protein characterization and quantitation in the context of systems biology. The core offers numerous services, from protein identification to C-terminal sequence analysis to intact protein molecular weight determination by ESI.

Small Molecule Mass Spectrometry Core

Offers access to electrospray, and MALDI-TOF mass spectrometers. A range of complete mass spectrometry services are available including intact protein MW measurement, MALDI-TOF (proteins, polymers, oligosaccharides etc.), targeted and untargeted LC-MS omics profiling, SRM quantification of drugs/metabolites, and much more.
Faculty Director: Matthew Shair

Neuroimaging Core

Offers access to a 3-Tesla magnetic resonance imaging scanner for non-invasive human brain imaging. The core is part of the Center for Brain Science, which operates the following additional cores: Neuroengineering, Light Microscopy, Electron Microscopy, and Mouse Genome Modification.
Faculty Director: Randy Buckner

Informatics & Scientific Applications Core

Offers access to bioinformatics analysis services for all users of the Core Sequencing facility and FAS faculty groups regardless of the origin of their data.
Director: Michele Clamp

Robotics Core Facility

Offers access to instruments for liquid handling, thermal cycling, and many other instruments.
Faculty Director: Michael Desai

Genome Modification Facility

Offers access to transgene microinjection, embryonic stem cell gene targeting, blastocyst injection, cryopreservation, strain rederivation, and EUCOMM/KOMP.
Faculty Director: Josh Sanes

HSCI iPS Cell Core Facility

Offers access to services and instrumentation that facilitate the derivation and distribution of iPS cell lines. The core houses iPS cells produced by HSCI scientists, and it functions as a laboratory to produce disease-specific lines.

Center for Crystallographic Studies (X-ray Core)

Offers access to the X-ray diffraction facility. The facility provides researchers with single crystal X-ray data collection, structure solution, and refinement of small molecule structures.
Faculty Director: Theodore Betley

Nuclear Magnetic Resonance (NMR) Core Facility

Offers access to nine different spectrometers.
Faculty Director: Matthew Shair

Research Computing

Offers cutting edge computational support and consultation. With more than 12,000 processing cores and numerous software modules and applications, Research Computing provides researchers the necessary tools for large-scale computing.

Center for Nanoscale Systems

A “build and test” laboratory facility supporting: cleanroom fabrication and characterization of nanoscale devices and structures; electron-beam imaging and analysis tools; materials characterization including XPS, microCT, PL, FTIR, AFM, microfluidic processing and a cell culture and microscopy facility.

Helium Liquefaction & Recovery Core

Offers Helium liquefaction and recovery services to laboratories.
Faculty Director: Gerald Gabrielse

MCB Graphic Design Facility

Offers graphic design support and training.

Physics Machine Shop

Offers machine shop training and classes.

Go here for a complete listing of all cores across Harvard (not just under the Division of Science).